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VOS3000 is one of the leading softswitch solutions provider which also offer VOS3000 VIRUS AND KEYGEN FREE keygen and one time setup service to your VOS3000 VIRUS FREE computer to get your VOS3000 2.1.4.0 FULL VERSION.The long-range goal of the proposed research is to understand the cellular and molecular basis for the structural and functional plasticity of brain white matter. This knowledge will be useful in characterizing the alterations in white matter structure that accompany neurological disease and normal aging, and in developing neuroprotective strategies for the treatment of patients with a variety of brain injuries and neurodegenerative disorders. Previous studies of white matter indicate that multiple changes occur in myelinating and non-myelinating glia as a result of experimental brain injury. This project will examine the long-term consequences of a focal ischemia in the parietal neocortex on the morphology of the developing white matter of the rat cerebral cortex. Both oligodendrocyte progenitor cells and immature oligodendrocytes will be identified immunocytochemically and characterized morphologically and ultrastructurally. Experiments will determine whether these cells participate in remyelination and in the maintenance of a stable glia limitans. The results will provide new information about the mechanisms by which the glia limitans is maintained and about how oligodendrocyte progenitor cells and immature oligodendrocytes are regulated by neuronal activity in vivo. Studies of the alterations in the normal aging brain are also proposed. The plan is to determine which regions of the brain lose myelin with age and what consequences this loss has for neuronal activity. The effect of age-related white matter loss on the morphology of the glia limitans, astrocyte processes and axonal profiles will be determined. The extent to which neuronal activity is disrupted in the aged rat will be determined by electrophysiological experiments. These studies should provide new information about the mechanisms of glial control of white matter structure and the effects of aging and neurological injury on white matter. The results of this work will also be relevant to studies of my be359ba680
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